Cyclic peptide

 

Cyclic peptides

Cyclic peptides are considerably more stable than linear peptides due to their resistance to proteases. They have attracted significant interest from the biotechnology and pharmaceutical industries. Biorunstar can synthesize several types of cyclic peptides, as listed below:

 

Peptides Head-to-Tail Cyclization

Head-to-tail peptides are easily assembled through the formation of an amide bond between the peptide's own N-terminus amine and C-terminus carboxylic acid. We perform this reaction with very high yields and routinely provide cyclic peptides with over 98% purity.

Peptides Side Chain Cyclization

Biorunstar has the capability to selectively protect and deprotect peptide side chains, enabling the formation of lactam bridges between lysine or diaminopropanoic acid and glutamic or aspartic acids. We can even perform multiple different sites for bridge formation.

Cys-Cys Disulfide Bridge Cyclization

Disulfide-rich cyclic peptides have generated great interest in the development of peptide-based therapeutics due to their exceptional stability toward chemical, enzymatic, or thermal attack. We routinely synthesize single, double and multiple disulfide bridges on peptides with very high purity yields.