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+86-0755 2308 4243
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Room 309, Meihua Building, Taiwan Industrial Park, No.2132 Songbai Road, Bao'an District, Shenzhen, China
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Integrin-Targeting Research & cyclo RGD Peptides
Integrins, particularly the particularly the α v β 3 subtype, play a pivotal role in mediating cell-extracellular matrix (ECM) interactions. Overexpression of these receptors is a hallmark of tumor angiogenesis and various solid tumors, making them primary targets for targeted drug delivery (PDC) and molecular imaging.
Figure 1: Molecular interaction model of Biorunstar's Cyclic RGD (cRGD) peptide binding to the Integrin αvβ3 active site, demonstrating how structural constraints (e.g., c(RGDfK)) provide enhanced affinity and metabolic stability for precise targeting.
Biorunstar provides a comprehensive portfolio of high-purity cyclic RGD (cRGD) peptides designed to mimic the natural binding motif with enhanced stability and binding affinity. As a reliable cRGD peptide supplier, we offer high-quality cyclic RGD peptide synthesis services to empower your integrin-targeting research and drug discovery.
Figure 2: Biological diagram illustrating Integrin αvβ3 heterodimer activation (from Bent/Inactive to Active state), native ligand binding (e.g., Fibronectin/Vitronectin), and downstream signaling pathways like FAK that mediate cell adhesion, migration, and survival.
Product Series: RGD & Analogs
We specialize in the synthesis of cyclic RGD motifs that offer superior enzymatic resistance and high binding affinity. Our portfolio includes specialized controls, dimers, and functionalized constructs for advanced R&D.
| Peptide Product | Sequence / Structure | Key Research Application | |
| c(RGDfK) | Cyclo(Arg-Gly-Asp-D-Phe-Lys) | Tumor imaging & site-specific conjugation via Lysine side chain. | |
| c(RGDfC) | Cyclo(Arg-Gly-Asp-D-Phe-Cys) | Precise conjugation via Thiol-Maleimide chemistry for gold nanoparticles. | |
| c(RADfK) | Cyclo(Arg-Ala-Asp-D-Phe-Lys) | Negative control peptide for integrin binding and cell adhesion assays. | |
| c(RGDyK(Mal)) | Maleimide-functionalized | Peptide-Drug Conjugate (PDC) Ready: Ideal for rapid, site-specific conjugation to thiol-containing drugs, proteins, or antibodies. | |
| c(RGDfV) | Cyclo(Arg-Gly-Asp-D-Phe-Val) | Standard high-affinity antagonist for α v β 3 binding inhibition assays. | |
| DOTA-E-[c(RGDfK)]2 | DOTA-conjugated Dimer | High-affinity precursor for 68Ga or 177Lu radiolabeling in tumor therapy. | |
| NHS-PEG5K-c(RGDyK)-CY7 | Dual-functional Probe, PEGylated RGD with NHS | NIR-Stealth Probe: Combines CY7 fluorescence with a PEG5K spacer for long-circulating PK tracing and covalent attachment via a long flexible space | |
| E[c(RGDyK)2 | Glutamate-linked Dimer | Dimeric RGD providing enhanced avidity and slower dissociation rates. | |
Technical Advantages of Biorunstar cyclo RGD Peptides
To ensure the accuracy of your cell adhesion assays and in vivo biodistribution studies, our peptides meet the highest industry standards:
High Purity (>98%): Each batch is verified by analytical HPLC and Mass Spectrometry (MS).
Optimized Salt Forms: Available in Acetate or HCl forms to minimize cellular toxicity in sensitive assays.
TFA-Free Options: Essential for cell culture studies to avoid interference with biological signaling.
Site-Specific Modifications: Expertise in conjugating CY Dyes (CY3, CY5, CY7), NHS esters, Maleimide (Mal), or Chelators (DOTA, NOTA) at precise positions.
Capabilities & Application Scope
Biorunstar's cRGD platform is engineered to support mission-critical research where Integrin α v β 3 affinity is the primary functional driver:
Molecular Imaging: Optimized for the development of high-contrast NIR fluorescent probes and radiolabeled tracers (PET/SPECT).
Precision Therapeutics: Serving as the targeting moiety for complex Peptide-Drug Conjugate (PDC) architectures.
Functional Bio-materials: High-affinity ligands for surface functionalization in Tissue Engineering and cell-adhesion studies.
Compliance & Ordering
Regulatory Statement: All products and services listed on this page are intended for laboratory research and development (R&D) purposes only. These materials are supplied as high-quality chemical intermediates and are not intended for direct human therapeutic use, clinical trials, or as finished pharmaceutical/cosmetic products.
Quality & Transparency: Every peptide is delivered with a comprehensive Certificate of Analysis (CoA), including analytical HPLC and Mass Spectrometry (MS) data to ensure reproducibility in your research.
Explore Our Expertise: We don't just supply peptides; we solve complex synthesis challenges. View Synthesis Cases
Request a Quote: For custom sequences, bulk scale-up, or technical consultations, please contact: Email: sales@biorunstar.com