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+86-0755 2308 4243
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Room 309, Meihua Building, Taiwan Industrial Park, No.2132 Songbai Road, Bao'an District, Shenzhen, China
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Neurodegenerative Disease Research: Advanced Peptide Tools
Neurodegenerative diseases such as Alzheimer's (AD), Parkinson's (PD), and Huntington's (HD) are closely linked to protein aggregation, including Amyloid-beta (Aβ), Tau, and α-synuclein.
Biorunstar provides high-purity peptide synthesis solutions to support aggregation studies, biomarker development, and CNS drug discovery.
Product Series: Peptide Portfolio for Neuroscience Research
We specialize in synthesizing challenging neuropeptides, including aggregation-prone sequences and blood–brain barrier (BBB) shuttle peptides. Our portfolio covers high-purity amyloid fragments, functional control peptides, and labeled probes to support advanced CNS drug discovery.
| Peptide Product | Sequence / Structure | Key Research Application | |
|
(CAS: 107761-42-2) |
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA |
Primary component of amyloid plaques in AD; extremely high-aggregation potential. | |
|
(CAS: 131438-79-4) |
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV |
Most abundant soluble Aβ isoform; essential for fibrillation and vascular amyloid studies. | |
|
(CAS: 166090-74-0) |
DAEFGHDSGFEVRHQKLVFFAEDVGSNKGAIIGLMVGGVVIA |
Commonly used in rodent models of Alzheimer's disease; differs from human Aβ by three substitutions at positions 5, 10, and 13. |
|
|
(CAS: 144409-98-3) |
DAEFGHDSGFEVRHQKLVFFAEDVGSNKGAIIGLMVGGVV |
Standard isoform for rodent-based neurotoxicity and behavioral studies. | |
|
Amyloid-β (42-1), Human (Reverse) (CAS: 317366-82-8) |
AIVVGGVMLGIIAGKNSGVDEAFFVLKQHHVEYGSDHRFEAD |
Negative control peptide to validate that biological effects are sequence-specific. | |
|
Amyloid-β (40-1), Human (Reverse) (CAS: 144409-99-4) |
VVGGVMLGIIAGKNSGVDEAFFVLKQHHVEYGSDHRFEAD |
Negative control used to differentiate specific aggregation from non-specific peptide effects. | |
|
(CAS: 131602-53-4) |
GSNKGAIIGLM | The shortest cytotoxic fragment of Aβ; used for rapid neurotoxicity screening. | |
|
Angiopep-2 |
TFFYGGSRGKRNNFKTEEY |
High-efficiency blood–brain barrier (BBB) shuttle; targets LRP1 for brain-targeted drug delivery. |
|
| RVG29 | YTIWMPENPRPGTPCDIFTNSRGKRASNG | Rabies Virus Glycoprotein fragment; neuron-specific targeting & blood–brain barrier (BBB) crossing. | |
| p-Tau (Thr231) Core Fragment, Human (Phosphorylated) | ATPPK(pT)PPGSG | Epitope Mapping: Target for p-Thr231 specific antibodies. | |
|
p-Tau (Thr231) Extended, Human, (Phosphorylated) |
KKVAVVR(pT)PPKSPSSAK | Extended fragment mimicking native Tau environment; optimized for GSK-3β and PP2A enzymatic assays | |
| α-Synuclein (61-95) | EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFV | Core Aggregation Domain: Known as the "Non-Amyloid Component" (NAC), this hydrophobic region is essential for α-synuclein fibrillization and insoluble Lewy body formation in Parkinson's Disease | |
|
(CAS: 33507-63-0) |
RPKPQQFFGLM-NH2 | Neuropeptide involved in neuroinflammation and pain signaling pathways. | |
|
NPY, Human/Rat (CAS: 82785-45-3) |
YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRY-NH2 | Major orexigenic neuropeptide modulating neuroprotective and stress response pathways. | |
Customization & Quality: Beyond Thr231, Biorunstar offers expert synthesis for critical Tau sites (e.g., p-Ser396, AT8 epitope, p-Ser199) and various modifications (FITC, CY3, CY5, CY7, Biotin, PEG, Azide). All peptides are verified by HPLC and MS to ensure high purity and precise phosphorylation occupancy.
Related Synthesis Cases & Inquiries
We specialize in the synthesis of high-hydrophobicity peptides (e.g., Aβ 1-42) with guaranteed monomeric control and optimized solubility for sensitive CNS assays.
Case Studies: See some of our recent synthesis projects at https://www.biorunstar.com/projects
Inquiries: sales@biorunstar.com