Isotope Labeled Peptide

 

Stable isotope-labeled peptides are developed as useful tools for quantitative peptide analysis or protein structure and dynamics determination using mass spectrometry (MS) or nuclear magnetic resonance (NMR) spectroscopy, as they have a known molecular weight difference. Biorunstar is committed to the highest quality in the manufacturing of stable isotope-labeled peptides.

 

Label Options

2H (deuterium)

15N

13C

15N and 13C combinations

Below lists is the most common stable isotopically labeled amino acids that can be used for the synthesis of peptides with stable isotopes containing carbon 13 (13C), Nitrogen 15 (15N) and Deuterium (2H). Other labeled amino acids are available upon request.

 

Amino Acid	Code	Isotope	Mass Difference	Isotopic enrichment
Alanine	Ala(A)	U- 13C3, U-15N	+4 Da	>99%
Arginine	Arg(R)	U- 13C6, U-15N4	+10 Da	>99%
Isoleucine	Ile(I)	U- 13C6, U-15N	+7Da	>99%
Leucine	Leu(L)	U- 13C6, U-15N	+7 Da	>99%
Lysine	Lys(K)	U- 13C6, U-15N2	+8 Da	>99%
Phenylalanine	Phe(F)	U- 13C9, U-15N	+10 Da	>99%
Proline	Pro(P)	U- 13C5, U-15N	+6 Da	>99%
Valine	Val(V)	U- 13C5, U-15N	+6 Da	>99%

 

Characteristic Features

Design of your peptide with the expected mass difference by choosing the plural stable isotope-labeled amino acids

Easy and efficient quantification of the natural peptide by MSA

Isotope is not radioactive

Possible assorted modifications such as disulfide bond formation

Direct analysis of samples from the living body without any prior treatments