Methylated Peptide

 

Methylated peptides are a common form of post-translational modifications (PTMs), including lysine, arginine, and cysteine methylation. Biorunstar has extensive experience in the synthesis of the following post-translationally modified peptides:

Arginine methylation Peptide Modification

Arginine methylated are involved in a number of different cellular processes, including transcriptional regulation, RNA metabolism and DNA damage repair. Their respective structures are shown as below:

 

Lysine Methylation Peptide Modification

Lysine methylation is restricted to a subset of proteins and catalysed by highly specific methyltransferases that can generate mono-, di-, and trimethylated lysines. These modifications result in changes in protein : protein interactions, chromatin structure and gene expression. Their respective structures are shown as below:

Glycosylation is one of the most common post-translational modifications of proteins, with significant effects on protein folding, conformation, distribution, stability and activity.

 

N-linked glycosylation

N-linked glycosylation are covalently attached to protein at asparagine (Asn) residues by an N-glycosidic, and is important for both the structure and function of some eukaryotic protein.

 

O-linked glycosylation

O-Linked glycosylation are form by a linkage between an amino acid hydroxyl side chain (usually from serine or threonine) with the glycan. The majority of O-linked glycans take the form GlcNac-β-Ser/Thr or GalNac-α-Ser/Thr.

 

Other PTMs

Myristoylation, Palmitoylation, Pyroglutamate(Pyr), Proline hydroxylation(Hyp).