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c(RGDfC) is a cyclic peptide containing the RGD sequence, which binds to integrin receptors, particularly αvβ3 integrins. It is used in cancer therapy and imaging to target tumor vasculature, as tumors often overexpress these integrins.
Specifications
|
Sequence one letter code |
cyclo(RGDfC) |
|
Sequence three letter code |
cyclo(Arg-Gly-Asp-d-Phe-Cys) |
|
CAS Number |
862772-11-0 |
|
Molecular Formula |
C24H34N8O7S1 |
|
Molecular Weight |
578.65 |
|
Modification |
Cyclization |
|
Purity |
Peak Area by HPLC ≥95% |
|
Form |
Lyophilized |
|
Long Storage |
- 20 °C or below |
| For Research Use Only. | |
Reference：
1. Pasqualini, R., & Arap, W. (2004). Cyclo(RGDfC) peptides in cancer targeting and imaging. Nature Reviews Cancer, 4(6), 528–537
2. Pierschbacher, M. D., & Ruoslahti, E. (1984). Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. Nature, 309(5963), 30–33.
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