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![DOTA-E-[c(RGDfK)2]](https://img01.v15cdn.com/nopic.webp)
DOTA-E-[c(RGDfK)2] is a dimeric peptide containing the RGD sequence, used as an integrin ligand for radiolabeling and positron emission tomography (PET) imaging. It is applied in vascular and tumor research to study angiogenesis and integrin-related processes.
Specifications
|
Sequence one letter code |
DOTA-E-[c(RGDfK)2] |
|
Sequence three letter code |
DOTA-Glu-[cyclo (Arg-Gly-Asp-d-Phe-Lys)] |
|
CAS Number |
N/A |
|
Molecular Formula |
C75H113N23O23 |
|
Molecular Weight |
1704.88 |
|
Modification |
Cyclization, DOTA |
|
Purity |
Peak Area by HPLC ≥95% |
|
Form |
Lyophilized |
|
Long Storage |
- 20 °C or below |
| For Research Use Only. | |
References:
1. Lopez-Rodriguez, V., Gaspar-Carcamo, R. E., Pedraza-Lopez, M., Rojas-Calderon, E. L., Arteaga de Murphy, C., Ferro-Flores, G., & Avila-Rodriguez, M. A. (2015). Preparation and preclinical evaluation of 66Ga-DOTA-E(c(RGDfK))₂ as a potential theranostic radiopharmaceutical. Nuclear Medicine and Biology, 42(2), 109-114.
2. Siitonen, R., Peuhu, E., Autio, A., Liljenbäck, H., Mattila, E., Metsälä, O., Käkelä, M., Saanijoki, T., Dijkgraaf, I., Jalkanen, S., Ivaska, J., & Roivainen, A. (2019). 68Ga-DOTA-E[c(RGDfK)]2 PET Imaging of SHARPIN-Regulated Integrin Activity in Mice. Journal of Nuclear Medicine, 60(10), 1380–1387.
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