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Myelin oligodendrocyte glycoprotein (MOG) 35-55, a minor component of central nervous system (CNS) myelin, is considered a target autoantigen in multiple sclerosis (MS). This peptide, a key immunodominant epitope of MOG, induces strong T and B cell responses, contributing to the development of experimental autoimmune encephalomyelitis (EAE) in rodents. The MOG 35-55 peptide produces a relapsing-remitting neurological disease characterized by extensive plaque-like demyelination, closely resembling the pathology observed in MS, making it a valuable model for studying the disease and its immunological mechanisms.
Specifications
|
Sequence one letter code |
MEVGWYRSPFSRVVHLYRNGK |
|
Sequence three letter code |
Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys |
|
CAS Number |
149635-73-4 |
|
Molecular Formula |
C118H177N35O29S1 |
|
Molecular Weight |
2581.99 |
|
Modification |
N/A |
|
Purity |
Peak Area by HPLC ≥95% |
|
Form |
Lyophilized |
|
Long Storage |
- 20 °C or below |
| For Research Use Only. | |
References:
1. Bettelli, E., Pagany, M., Weiner, H. L., Linington, C., Sobel, R. A., & Kuchroo, V. K. (2003). Myelin oligodendrocyte glycoprotein–specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. Journal of Experimental Medicine, 197(9), 1073–1081.
2. Williams, J. L., Kithcart, A. P., Smith, K. M., Shawler, T., Cox, G. M., & Whitacre, C. C. (2011). Memory cells specific for myelin oligodendrocyte glycoprotein (MOG) govern the transfer of experimental autoimmune encephalomyelitis. Journal of Neuroimmunology, 234(1–2), 84–92.
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