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HIV-Tat (47-57) is derived from the HIV-1 transactivator of transcription (Tat) protein, specifically from its basic domain comprising amino acids 47 to 57 (sequence: YGRKKRRQRRR). This short peptide is known for its remarkable cell-penetrating capability, enabling it to cross cellular membranes and deliver various biomolecules into cells.
Specifications
|
Sequence one letter code |
YGRKKRRQRRR |
|
Sequence three letter code |
Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg |
|
CAS Number |
191936-91-1 |
|
Molecular Formula |
C64H118N32O14 |
|
Molecular Weight |
1558.95 |
|
Modification |
N/A |
|
Purity |
Peak Area by HPLC ≥95% |
|
Form |
Lyophilized |
|
Long Storage |
- 20 °C or below |
| For Research Use Only. | |
References:
1.Wadia, J. S., & Dowdy, S. F. (2002). Protein transduction technology. Current Opinion in Biotechnology, 13(1), 52–56.
2. Vives, E., Brodin, P., & Lebleu, B. (1997). A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus. Journal of Biological Chemistry, 272(25), 16010–16017.
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